Jim Carrey

Lloyd Christmas

Jeff Daniels

Harry Dunne

Laurie Holden

Adele

Rachel Melvin

Penny

Kathleen Turner

Fraida

Rob Riggle

Travis / Captain Lippincott

Tembi Locke

Dr. Walcott

Paul Blackthorne

Emergency Room Doctor

Brady Bluhm

Billy

Patricia French

Ms. Sourpuss

Steve Tom

Dr. Pinchelow

Don Lake

Dr. Meldman

Eddie Shin

Gordy

Atkins Estimond

Gus

Tommy Snider

Tom

Lindsay Ayliffe

Professor Garabedian

Matty Cardarople

Inventor No. 1

Bill Murray

Ice Pick

Grant James

Mr. Stainer

Taylor St. Clair

Mrs. Steiner

Erin Allin O'Reilly

Asylum Nurse No. 1

Walt Arnett

KEN Audience Member

Erika Bierman

Fanny at Age 13

Kassidy Claire

Fanny at Age 5

Carly Craig

Young Fraida

Bryan Dilbeck

Dr. Dilbeck

Dalton E. Gray

Young Harry

Michael McCrudden

Audience Member

June Shannon

Harry's Trailer Park Wife

Maia Moss-Fife

Receptionist

Jeff Sumner

Convention Official

Julius Sharpe

KEN Conference Attendee

David Roland Walpole

KEN Conference Attendee

Elizabeth Cooper

Mrs. Julie James

Michael Yama

Harry's Dad

Nancy Byers Farrelly

Asylum Nurse #2

Derek Holland

Asylum Patient

Brendan Boyle

Asylum Patient

Swizz Beatz

Ninja Leader

Mike Cerrone

Trucker

Sean Gildea

Trucker's Pal

Brett Wyman

Inventor #2

Jo Helton

Mrs. Snergle

Edward Barbanell

Nursing Home Orderly

Mariann Neary

Farmer's Wife

John Imlay

Farmer

Jon Barinholtz

Inventor No. 3

Lucas Daniels

Bartender

Carter Hicks

Bus Kid

Baxter Cooper Rogers

Prom Date

Sandra Dorsey

Stuffy Woman

Arielle Liberman

Emergency Room Nurse

Jon Barry

Emergency Room Orderly

Jesse Gines

Emergency Room Orderly

Robin O'Neal Sorensen

Emergency Medical Technician #1

Chris Randall Sorensen

Emergency Medical Technician #2

Daniel Greene

Wheelchair Ninja

Will Coogan

Room Service Waiter

Caryle Seim

Trailer Grandma

Danny Murphy

Joystick Victim

Paul Bednarz

KEN Convention Employee (uncredited)

Jennifer Cocker

Young Inventor (uncredited)

John Deifer

Mental Patient (uncredited)

Gregory Fears

Man at Gas Station (uncredited)

Abigail Gamache

Prom Attendee (uncredited)

William Goodrum

Prom Singer (uncredited)

Walter Hendrix III

Street Patron (uncredited)

Angela Kerecz

Waitress (uncredited)

John Merical

Neighbor (uncredited)

Rhomeyn Johnson

Bus Driver

Nancy Yee

Harry's Mom

John Viener

KEN Conference Attendee

Rocky Russo

KEN Conference Attendee

Wellesley Wild

KEN Conference Attendee

Jeremy Garelick

KEN Conference Attendee

Ricky Blitt

KEN Conference Attendee

Jeremy Sosenko

KEN Conference Attendee

Kevin Barnett

KEN Conference Attendee

Patrick Meighan

KEN Conference Attendee

Chris Sheridan

KEN Conference Attendee

Danny Smith

KEN Conference Attendee

Cam Neely

Sea Bass (uncredited)